HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: S10AC (P80511)
Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
Gene: S100A12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	S_100~TAD2
Common GO terms	GO:0005507 - copper ion binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 92
+	Hs
		387043 P53_HUMAN (1-393): 0: 619: 100.00		HORN_HUMAN (1-92): 1.6e-34: 125: 33.70
+	Hs
		386132 P53_HUMAN (1-393): 0: 619: 100.00		S100P_HUMAN (1-91): 4.22e-34: 114: 45.06
+	Hs
		386185 P53_HUMAN (1-393): 0: 619: 100.00		S10AB_HUMAN (2-91): 6.03e-34: 114: 36.67
+	Hs
		386104 P53_HUMAN (1-393): 0: 619: 100.00		S10A1_HUMAN (2-91): 2.44e-33: 112: 37.78
+	Hs
		386865 P53_HUMAN (1-393): 0: 619: 100.00		FILA2_HUMAN (1-92): 1.71e-29: 111: 36.96
+	Hs
		380714 P53_HUMAN (1-393): 0: 619: 100.00		S100B_HUMAN (1-92): 3.09e-30: 104: 38.04
+	Hs
		386137 P53_HUMAN (1-393): 0: 619: 100.00		S10A4_HUMAN (3-90): 2.12e-30: 104: 34.09
+	Hs
		386155 P53_HUMAN (1-393): 0: 619: 100.00		S10A2_HUMAN (2-90): 1.46e-29: 102: 35.96
+	Hs
		386412 P53_HUMAN (1-393): 0: 619: 100.00		S10AA_HUMAN (2-89): 1.9e-29: 102: 31.82
+	Hs
		386192 P53_HUMAN (1-393): 0: 619: 100.00		S10A3_HUMAN (3-89): 2.61e-28: 99.5: 32.18
+	Hs
		385910 P53_HUMAN (1-393): 0: 619: 100.00		S10A8_HUMAN (1-92): 6.32e-26: 93.3: 38.04
+	Hs
		387288 P53_HUMAN (1-393): 0: 619: 100.00		S10AG_HUMAN (2-92): 3.24e-25: 91.8: 25.00
+	Hs
		385924 P53_HUMAN (1-393): 0: 619: 100.00		S10A6_HUMAN (3-87): 3.68e-24: 88.7: 37.65
+	Hs
		386191 P53_HUMAN (1-393): 0: 619: 100.00		S10A5_HUMAN (2-92): 1.07e-22: 85.2: 35.17
+	Hs
		386596 P53_HUMAN (1-393): 0: 619: 100.00		TRHY_HUMAN (1-91): 2.53e-19: 82.6: 28.57
+	Hs
		387371 P53_HUMAN (1-393): 0: 619: 100.00		S10AD_HUMAN (1-83): 1.32e-21: 82.6: 34.94