HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23402884
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 1038
+	Hs
		175860 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		ACK1_HUMAN (1-1038): 0: 805: 100.00
+	Hs
		337302 P53_HUMAN (1-393): 0: 619: 100.00		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		262217 P53_HUMAN (1-393): 0: 619: 100.00		ULK1_HUMAN (113-957): 7.3e-139: 446: 19.95
+	Hs
		386581 P53_HUMAN (1-393): 0: 619: 100.00		FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01
+	Hs
		386778 P53_HUMAN (1-393): 0: 619: 100.00		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		386959 P53_HUMAN (1-393): 0: 619: 100.00		LMTK1_HUMAN (84-959): 2.68e-126: 419: 21.75
+	Hs
		386000 P53_HUMAN (1-393): 0: 619: 100.00		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		386158 P53_HUMAN (1-393): 0: 619: 100.00		EPHA3_HUMAN (109-456): 3.37e-117: 386: 30.34
+	Mm
		356894 P53_MOUSE (1-393): 0: 589: 77.35		FAK2_MOUSE (29-692): 3.69e-126: 411: 22.02
+	Hs
		385938 P53_HUMAN (1-393): 0: 619: 100.00		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79
+	Hs
		175803 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		175811 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		HCK_HUMAN (76-388): 8.7e-112: 358: 34.40