HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 726
+	Hs
		386125 P53_HUMAN (1-393): 0: 619: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		386862 P53_HUMAN (1-393): 0: 619: 100.00		BRDT_HUMAN (18-695): 2.15e-107: 350: 49.71
+	Hs
		386779 P53_HUMAN (1-393): 0: 619: 100.00		ZMY11_HUMAN (3-446): 1.03e-44: 171: 9.63
+	Hs
		386615 P53_HUMAN (1-393): 0: 619: 100.00		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		387226 P53_HUMAN (1-393): 0: 619: 100.00		KAT2A_HUMAN (267-414): 1.15e-33: 140: 28.86
+	Hs
		387227 P53_HUMAN (1-393): 0: 619: 100.00		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Hs
		387715 P53_HUMAN (1-393): 0: 619: 100.00		BRPF3_HUMAN (37-484): 7.42e-31: 132: 14.82
+	Mm
		70883 P53_MOUSE (1-393): 0: 589: 77.35		EP300_MOUSE (4-177): 2.63e-34: 143: 22.86
+	Hs
		387439 P53_HUMAN (1-393): 0: 619: 100.00		CECR2_HUMAN (134-594): 1.39e-24: 112: 14.23
+	Mm
		356829 P53_MOUSE (1-393): 0: 589: 77.35		CBP_MOUSE (19-143): 6.81e-32: 136: 30.23
+	Mm
		101415 P53_MOUSE (1-393): 0: 589: 77.35		F8VPR5_MOUSE (19-143): 9.58e-32: 135: 30.23
+	Hs
		243780 P53_HUMAN (1-393): 0: 619: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		386088 P53_HUMAN (1-393): 0: 619: 100.00		TAF1_HUMAN (23-303): 3.47e-17: 88.7: 13.52
+	Hs
		175861 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		175902 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Hs
		999088 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		1271496 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Dm
		1341797 Q9N6D8_DROME (124-325): 3.11e-77: 245: 24.31		Q9VTZ1_DROME (267-415): 9.98e-35: 143: 29.61
+	Dm
		1341765 Q9N6D8_DROME (124-325): 3.11e-77: 245: 24.31		Q9VCG6_DROME (273-565): 1.87e-20: 97.6: 15.36