HitPredict - High confidence protein-protein interactions

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.743

Property	Details
Experiments	27345397, 11593383, 10640274, 9537326, 15629713, 12606552, 12124396, unassigned1913
Identification Methods	affinity chromatography technology, pull down, split luciferase complementation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000987 - cis-regulatory region sequence-specific DNA binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific and 22 others more... GO:0002039 - p53 binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0007405 - neuroblast proliferation GO:0010628 - positive regulation of gene expression GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0042826 - histone deacetylase binding GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity GO:0051402 - neuron apoptotic process GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0071456 - cellular response to hypoxia GO:1902895 - positive regulation of miRNA transcription GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	826

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Last updated: 15 Jul 2024