HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	31570706, 15989956, 22552282
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 1 others more... GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 4374
+	Mm
		356871 P53_MOUSE (1-393): 0: 589: 77.35		HUWE1_MOUSE (1-4374): 0: 3203: 96.37
+	Hs
		387302 P53_HUMAN (1-393): 0: 619: 100.00		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		125079 P53_HUMAN (1-393): 0: 619: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		387553 P53_HUMAN (1-393): 0: 619: 100.00		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Hs
		387482 P53_HUMAN (1-393): 0: 619: 100.00		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		386980 P53_HUMAN (1-393): 0: 619: 100.00		HECW1_HUMAN (3082-4373): 1.49e-161: 549: 18.31
+	Hs
		387650 P53_HUMAN (1-393): 0: 619: 100.00		HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49
+	Hs
		175909 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		125008 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		1294857 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		175923 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		175841 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Hs
		1327910 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		175932 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49
+	Hs
		808269 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46