HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HERC6 (Q8IVU3)
Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6)
Gene: HERC6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32807901
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002244 - hematopoietic progenitor cell differentiation GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 1022
+	Hs
		386758 P53_HUMAN (1-393): 0: 619: 100.00		HERC3_HUMAN (2-1014): 0: 945: 37.76
+	Hs
		387686 P53_HUMAN (1-393): 0: 619: 100.00		HERC5_HUMAN (2-1014): 0: 916: 47.95
+	Hs
		387302 P53_HUMAN (1-393): 0: 619: 100.00		ITCH_HUMAN (508-1014): 0: 579: 19.39
+	Hs
		387482 P53_HUMAN (1-393): 0: 619: 100.00		WWP1_HUMAN (515-1014): 0: 556: 19.62
+	Hs
		125079 P53_HUMAN (1-393): 0: 619: 100.00		WWP2_HUMAN (325-1014): 0: 554: 16.92
+	Hs
		386980 P53_HUMAN (1-393): 0: 619: 100.00		HECW1_HUMAN (461-1014): 2.59e-174: 553: 20.11
+	Hs
		386580 P53_HUMAN (1-393): 0: 619: 100.00		UBE3A_HUMAN (402-1014): 1.36e-175: 536: 24.49
+	Hs
		387650 P53_HUMAN (1-393): 0: 619: 100.00		HECW2_HUMAN (492-1014): 4.33e-165: 527: 20.34
+	Hs
		387553 P53_HUMAN (1-393): 0: 619: 100.00		SMUF1_HUMAN (548-1014): 1.29e-164: 504: 21.65
+	Hs
		175909 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		ITCH_HUMAN (508-1014): 0: 579: 19.39
+	Hs
		175841 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		NEDD4_HUMAN (566-1014): 3.48e-179: 559: 21.73
+	Hs
		175923 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP1_HUMAN (515-1014): 0: 556: 19.62
+	Hs
		125008 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP2_HUMAN (325-1014): 0: 554: 16.92
+	Hs
		1294857 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		ITCH_HUMAN (508-1014): 0: 579: 19.39
+	Hs
		175932 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		HECW2_HUMAN (492-1014): 4.33e-165: 527: 20.34
+	Hs
		808269 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		NEDD4_HUMAN (566-1014): 3.48e-179: 559: 21.73
+	Hs
		1327910 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		WWP1_HUMAN (515-1014): 0: 556: 19.62
+	Hs
		319694 P53_HUMAN (1-393): 0: 619: 100.00		HERC2_HUMAN (699-1009): 8.5e-15: 82: 26.89
+	Mm
		356853 P53_MOUSE (1-393): 0: 589: 77.35		HERC2_MOUSE (699-1009): 3.99e-14: 79.7: 26.59