HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25609649, 31152661, 34591612, 34591642, 22653443
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 598
+	Hs
		387246 P53_HUMAN (1-393): 0: 619: 100.00		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		387771 P53_HUMAN (1-393): 0: 619: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		387700 P53_HUMAN (1-393): 0: 619: 100.00		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		386436 P53_HUMAN (1-393): 0: 619: 100.00		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		386946 P53_HUMAN (1-393): 0: 619: 100.00		TRAF7_HUMAN (257-500): 1.2e-22: 104: 17.38
+	Hs
		1281386 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		386621 P53_HUMAN (1-393): 0: 619: 100.00		TBL3_HUMAN (73-236): 2.09e-15: 81.8: 15.48
+	Hs
		1330016 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22