HitPredict - High confidence protein-protein interactions

Interactor 1: APOA1 (P02647)
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]
Gene: APOA1

Interactor 2: APOC3 (P02656)
Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)
Gene: APOC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.55	0.585

Property	Details
Experiments	37343697, 15174051
Identification Methods	cross-linking study, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005543 - phospholipid binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005769 - early endosome GO:0007186 - G protein-coupled receptor signaling pathway and 14 others more... GO:0010903 - negative regulation of very-low-density lipoprotein particle remodeling GO:0015485 - cholesterol binding GO:0032489 - regulation of Cdc42 protein signal transduction GO:0033344 - cholesterol efflux GO:0033700 - phospholipid efflux GO:0034361 - very-low-density lipoprotein particle GO:0034366 - spherical high-density lipoprotein particle GO:0034375 - high-density lipoprotein particle remodeling GO:0042627 - chylomicron GO:0042632 - cholesterol homeostasis GO:0043691 - reverse cholesterol transport GO:0070062 - extracellular exosome GO:0070328 - triglyceride homeostasis GO:0070653 - high-density lipoprotein particle receptor binding
Homologous interactions	0

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Last updated: 11Aug2025