HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: MUL1 (Q969V5)
Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)
Gene: MUL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.707

Property	Details
Experiments	35048531, 21597459, 31235254, 31929179
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, enzymatic study
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002039 - p53 binding GO:0005739 - mitochondrion GO:0030308 - negative regulation of cell growth GO:0031625 - ubiquitin protein ligase binding GO:0050821 - protein stabilization
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 352
+	Hs
		175905 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		MUL1_HUMAN (1-352): 2.04e-125: 365: 100.00
+	Hs
		386678 P53_HUMAN (1-393): 0: 619: 100.00		BIRC3_HUMAN (36-352): 1.47e-66: 222: 15.25
+	Hs
		387334 P53_HUMAN (1-393): 0: 619: 100.00		RN157_HUMAN (129-349): 2.08e-32: 129: 15.56
+	Hs
		387202 P53_HUMAN (1-393): 0: 619: 100.00		RFFL_HUMAN (222-352): 1.75e-21: 95.7: 21.81
+	Hs
		387247 P53_HUMAN (1-393): 0: 619: 100.00		RNF34_HUMAN (252-352): 2.99e-20: 92.6: 28.71