HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	38580884, 9194565
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005654 - nucleoplasm GO:0042981 - regulation of apoptotic process GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 3159
+	Hs
		229278 P53_HUMAN (1-393): 0: 619: 100.00		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		386152 P53_HUMAN (1-393): 0: 619: 100.00		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		387557 P53_HUMAN (1-393): 0: 619: 100.00		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		387517 P53_HUMAN (1-393): 0: 619: 100.00		SMRCD_HUMAN (1895-2052): 1.85e-24: 115: 38.27
+	Hs
		386967 P53_HUMAN (1-393): 0: 619: 100.00		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		387646 P53_HUMAN (1-393): 0: 619: 100.00		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		386342 P53_HUMAN (1-393): 0: 619: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Mm
		356875 P53_MOUSE (1-393): 0: 589: 77.35		EP400_MOUSE (2511-3159): 1.94e-10: 69.5: 10.79
+	Mm
		356850 P53_MOUSE (1-393): 0: 589: 77.35		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57