HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: PLK3 (Q9H4B4)
Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)
Gene: PLK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

The method score is based on:

Property	Details
Experiments	11551930, 12242661
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus and 5 others more... GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0006974 - DNA damage response GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0043066 - negative regulation of apoptotic process
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	646

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024