Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53
Interactor 2: SMYD2 (Q9NRG4)
N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)
Gene: SMYD2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.88 | 0.60 | 0.730 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17108971, 18065756, 17805299, 21782458, 25609649 |
| Identification Methods | affinity chromatography technology, enzymatic study, methyltransferase assay, x-ray crystallography, isothermal titration calorimetry, methyltransferase radiometric assay, tandem affinity purification |
| Interaction Type | physical association, direct interaction, adp ribosylation reaction, methylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 3 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
