HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0008104 - protein localization GO:0043065 - positive regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 1088
+	Hs
		325589 P53_HUMAN (1-393): 0: 619: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		386774 P53_HUMAN (1-393): 0: 619: 100.00		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		386178 P53_HUMAN (1-393): 0: 619: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		386351 P53_HUMAN (1-393): 0: 619: 100.00		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		386785 P53_HUMAN (1-393): 0: 619: 100.00		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		175819 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		175823 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		386676 P53_HUMAN (1-393): 0: 619: 100.00		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77