HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	32807901, 25071020, 35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 1024
+	Hs
		386580 P53_HUMAN (1-393): 0: 619: 100.00		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		387482 P53_HUMAN (1-393): 0: 619: 100.00		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125079 P53_HUMAN (1-393): 0: 619: 100.00		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		387302 P53_HUMAN (1-393): 0: 619: 100.00		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		386980 P53_HUMAN (1-393): 0: 619: 100.00		HECW1_HUMAN (532-1024): 4.53e-156: 504: 22.94
+	Hs
		387650 P53_HUMAN (1-393): 0: 619: 100.00		HECW2_HUMAN (534-1024): 2.54e-153: 496: 23.43
+	Hs
		387553 P53_HUMAN (1-393): 0: 619: 100.00		SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71
+	Hs
		175923 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125008 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		175841 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		175909 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		175932 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		HECW2_HUMAN (534-1024): 2.54e-153: 496: 23.43
+	Hs
		1327910 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		1294857 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		808269 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		387051 P53_HUMAN (1-393): 0: 619: 100.00		HERC6_HUMAN (7-207): 4.36e-23: 108: 15.21
+	Hs
		386758 P53_HUMAN (1-393): 0: 619: 100.00		HERC3_HUMAN (317-460): 3.68e-11: 69.7: 10.88