HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	21521785, 19196987
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 605
+	Hs
		387700 P53_HUMAN (1-393): 0: 619: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1330016 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		387246 P53_HUMAN (1-393): 0: 619: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		386436 P53_HUMAN (1-393): 0: 619: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		386946 P53_HUMAN (1-393): 0: 619: 100.00		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		1281386 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71