HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	25277244, 20618440
Identification Methods	two hybrid, affinity chromatography technology, reverse ras recruitment system
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	14-3-3~HSP20
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 245
+	Hs
		388356 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		388366 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		388256 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		388393 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		147848 HSPB6_HUMAN (3-165): 2.25e-39: 134: 35.12		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		147847 HSPB6_HUMAN (3-165): 2.25e-39: 134: 35.12		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33