HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0043066 - negative regulation of apoptotic process GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 596
+	Hs
		388395 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCZ_HUMAN (15-596): 0: 631: 70.34
+	Hs
		388384 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCE_HUMAN (43-590): 1.72e-177: 521: 36.23
+	Hs
		388396 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52
+	Mm
		537687 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		KPCE_MOUSE (43-590): 1.96e-177: 521: 35.57
+	Mm
		537688 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		KPCD_MOUSE (93-589): 2.66e-177: 519: 35.40
+	Mm
		554863 CRYAB_MOUSE (18-197): 2.31e-51: 165: 38.89		KPCE_MOUSE (43-590): 1.96e-177: 521: 35.57
+	Hs
		388255 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Mm
		537689 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		AKT1_MOUSE (181-586): 6.16e-152: 447: 37.86
+	Hs
		358932 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		AKT3_HUMAN (120-586): 3.11e-152: 448: 33.19
+	Mm
		682124 HSPB2_MOUSE (1-181): 3.51e-43: 144: 33.88		AKT1_MOUSE (181-586): 6.16e-152: 447: 37.86
+	Hs
		388322 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KS6A3_HUMAN (122-543): 1.57e-104: 333: 20.47
+	Hs
		270358 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		KS6A5_HUMAN (62-540): 2.04e-118: 371: 17.96
+	Hs
		388151 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28
+	Hs
		388210 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37
+	Hs
		388146 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCG_HUMAN (107-190): 1.32e-12: 72.8: 39.29