HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	29491746, 31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0035556 - intracellular signal transduction GO:0043066 - negative regulation of apoptotic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 592
+	Hs
		388280 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		388396 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26
+	Mm
		537688 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		KPCD_MOUSE (63-585): 9.16e-180: 525: 34.35
+	Hs
		388255 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Mm
		537689 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		AKT1_MOUSE (172-582): 4.54e-154: 452: 36.39
+	Hs
		358932 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		AKT3_HUMAN (171-582): 2.36e-153: 450: 37.24
+	Mm
		682124 HSPB2_MOUSE (1-181): 3.51e-43: 144: 33.88		AKT1_MOUSE (172-582): 4.54e-154: 452: 36.39
+	Hs
		388322 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47
+	Hs
		388384 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Mm
		537687 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		KPCE_MOUSE (6-190): 3.27e-27: 118: 18.91
+	Hs
		388151 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCB_HUMAN (85-187): 1.04e-21: 101: 27.18
+	Hs
		388210 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Hs
		388146 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCG_HUMAN (116-180): 1.87e-10: 65.9: 36.92
+	Mm
		554863 CRYAB_MOUSE (18-197): 2.31e-51: 165: 38.89		KPCE_MOUSE (6-190): 3.27e-27: 118: 18.91