HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005819 - spindle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 448
+	Hs
		388255 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		388431 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KCC1A_HUMAN (157-445): 7.74e-123: 363: 21.55
+	Mm
		537689 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		AKT1_MOUSE (59-444): 7.18e-124: 370: 17.57
+	Hs
		388405 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		388409 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		388386 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		MP2K1_HUMAN (139-448): 1.69e-102: 312: 40.57
+	Hs
		358932 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		AKT3_HUMAN (111-444): 6.73e-124: 370: 20.34
+	Mm
		682124 HSPB2_MOUSE (1-181): 3.51e-43: 144: 33.88		AKT1_MOUSE (59-444): 7.18e-124: 370: 17.57
+	Hs
		388294 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09