HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.637

Property	Details
Experiments	25147182, 25277244
Identification Methods	affinity chromatography technology, two hybrid, reverse ras recruitment system, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 4374
+	Hs
		125080 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		388717 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		388735 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		SMUF2_HUMAN (3771-4371): 0: 611: 33.44
+	Hs
		359059 CRYAB_HUMAN (18-197): 6.14e-51: 164: 39.44		NED4L_HUMAN (3542-4372): 0: 618: 27.53