HitPredict - High confidence protein-protein interactions

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	G-alpha~G-alpha
Common GO terms	GO:0001664 - G protein-coupled receptor binding GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 12 others more... GO:0005813 - centrosome GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007049 - cell cycle GO:0007193 - adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007194 - negative regulation of adenylate cyclase activity GO:0016020 - membrane GO:0030496 - midbody GO:0031683 - G-protein beta/gamma-subunit complex binding GO:0046872 - metal ion binding GO:0051301 - cell division GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	355
Hs

1	354

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024