HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: C5AR1 (P21730)
C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)
Gene: C5AR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	7962171
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 350
+	Hs
		391305 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		ADRB2_HUMAN (42-346): 7.28e-71: 228: 17.65
+	Hs
		444666 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		C5AR1_HUMAN (1-350): 1.33e-76: 240: 100.00
+	Hs
		429011 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		ADRB2_HUMAN (42-346): 7.28e-71: 228: 17.65
+	Hs
		391347 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		OPRD_HUMAN (5-344): 1.09e-67: 218: 23.65
+	Hs
		428884 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		ADRB2_HUMAN (42-346): 7.28e-71: 228: 17.65
+	Hs
		450984 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRD_HUMAN (5-344): 1.09e-67: 218: 23.65
+	Hs
		450979 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRM_HUMAN (1-346): 5.02e-67: 217: 23.03
+	Hs
		428911 GNAT2_HUMAN (1-355): 1.04e-166: 470: 69.86		ADRB2_HUMAN (42-346): 7.28e-71: 228: 17.65
+	Hs
		670432 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		P2RY1_HUMAN (9-349): 4.59e-74: 235: 21.94
+	Hs
		686617 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CCR1_HUMAN (23-318): 1.17e-67: 218: 24.25
+	Hs
		674835 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		AGTR1_HUMAN (26-348): 2.87e-67: 217: 23.65
+	Hs
		670446 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		CXCR4_HUMAN (6-323): 1.6e-67: 217: 26.24
+	Hs
		686657 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CCR1_HUMAN (23-318): 1.17e-67: 218: 24.25
+	Hs
		895622 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CXCR4_HUMAN (6-323): 1.6e-67: 217: 26.24
+	Hs
		429010 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		ADRB2_HUMAN (42-346): 7.28e-71: 228: 17.65