HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: CXCR1 (P25024)
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
Gene: CXCR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	8903513, 8662698
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 350
+	Hs
		391305 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		ADRB2_HUMAN (33-336): 3.28e-68: 221: 19.65
+	Hs
		391338 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24
+	Hs
		429011 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		ADRB2_HUMAN (33-336): 3.28e-68: 221: 19.65
+	Hs
		391347 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		OPRD_HUMAN (2-348): 5.86e-64: 209: 25.63
+	Hs
		428884 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		ADRB2_HUMAN (33-336): 3.28e-68: 221: 19.65
+	Hs
		450977 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24
+	Hs
		450979 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRM_HUMAN (2-350): 3.04e-65: 213: 25.91
+	Hs
		450984 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRD_HUMAN (2-348): 5.86e-64: 209: 25.63
+	Hs
		428911 GNAT2_HUMAN (1-355): 1.04e-166: 470: 69.86		ADRB2_HUMAN (33-336): 3.28e-68: 221: 19.65
+	Hs
		686617 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CCR1_HUMAN (28-349): 5.07e-69: 221: 29.27
+	Hs
		674835 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		AGTR1_HUMAN (35-347): 1.08e-67: 218: 30.12
+	Hs
		687035 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24
+	Hs
		670426 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24
+	Hs
		670446 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		CXCR4_HUMAN (28-320): 8.03e-67: 215: 36.74
+	Bt
		362125 GNAT1_BOVIN (1-355): 6.59e-165: 465: 65.92		OPSD_BOVIN (2-342): 2.34e-62: 204: 18.13
+	Hs
		686657 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CCR1_HUMAN (28-349): 5.07e-69: 221: 29.27
+	Hs
		687038 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24
+	Hs
		895622 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CXCR4_HUMAN (28-320): 8.03e-67: 215: 36.74
+	Hs
		429010 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		ADRB2_HUMAN (33-336): 3.28e-68: 221: 19.65