HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: PAR1 (P25116)
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Gene: F2R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 8982657
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~G-alpha
Common GO terms GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0030335 - positive regulation of cell migration
GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 355
Hs

1 425
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024