HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: CXCR5 (P32302)
C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)
Gene: CXCR5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	23773523, 15251452
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, coimmunoprecipitation, experimental interaction detection
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 372
+	Hs
		450977 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		CXCR5_HUMAN (1-372): 1.08e-91: 281: 100.00
+	Hs
		687035 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CXCR5_HUMAN (1-372): 1.08e-91: 281: 100.00
+	Hs
		391333 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		CXCR1_HUMAN (19-351): 1.47e-75: 239: 36.94
+	Hs
		670426 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		CXCR5_HUMAN (1-372): 1.08e-91: 281: 100.00
+	Hs
		687038 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CXCR5_HUMAN (1-372): 1.08e-91: 281: 100.00
+	Hs
		391347 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		OPRD_HUMAN (31-366): 5.92e-64: 209: 24.06
+	Hs
		450979 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRM_HUMAN (3-370): 2.84e-65: 214: 25.46
+	Hs
		450984 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRD_HUMAN (31-366): 5.92e-64: 209: 24.06
+	Hs
		686617 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CCR1_HUMAN (33-367): 2.52e-71: 228: 27.68
+	Hs
		674835 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		AGTR1_HUMAN (28-370): 3.38e-66: 215: 28.08
+	Hs
		670446 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		CXCR4_HUMAN (9-339): 4.68e-67: 217: 31.72
+	Hs
		686657 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CCR1_HUMAN (33-367): 2.52e-71: 228: 27.68
+	Hs
		895622 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CXCR4_HUMAN (9-339): 4.68e-67: 217: 31.72