HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: CRFR1 (P34998)
Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Gene: CRHR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22247544
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_2~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 415
+	Hs
		714730 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00
+	Hs
		450978 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00
+	Hs
		714727 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00
+	Hs
		926674 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		PTH1R_HUMAN (41-411): 1.43e-98: 307: 29.66
+	Hs
		714729 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00
+	Hs
		686272 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		VIPR1_HUMAN (19-409): 1.76e-94: 292: 27.86
+	Hs
		793723 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		GLP1R_HUMAN (2-413): 1.37e-95: 295: 27.52
+	Hs
		686282 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		VIPR1_HUMAN (19-409): 1.76e-94: 292: 27.86
+	Hs
		677567 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		CALCR_HUMAN (37-397): 3.04e-90: 282: 30.00