HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: MTR1B (P49286)
Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)
Gene: MTNR1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	26514267, 17215244
Identification Methods	pull down, tandem affinity purification
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0045202 - synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 362
+	Hs
		825681 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		MTR1B_HUMAN (1-362): 9.76e-84: 260: 100.00
+	Hs
		391305 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		ADRB2_HUMAN (1-347): 1.24e-78: 248: 17.55
+	Hs
		444688 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		MTR1B_HUMAN (1-362): 9.76e-84: 260: 100.00
+	Hs
		429011 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		ADRB2_HUMAN (1-347): 1.24e-78: 248: 17.55
+	Hs
		926680 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		MTR1L_HUMAN (30-360): 1.36e-74: 244: 45.37
+	Hs
		391347 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		OPRD_HUMAN (3-349): 4.7e-74: 235: 21.59
+	Hs
		428884 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		ADRB2_HUMAN (1-347): 1.24e-78: 248: 17.55
+	Hs
		450984 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRD_HUMAN (3-349): 4.7e-74: 235: 21.59
+	Hs
		450979 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRM_HUMAN (5-362): 2.06e-73: 234: 20.39
+	Hs
		391352 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		MTR1A_HUMAN (36-354): 2.47e-66: 215: 62.38
+	Hs
		428911 GNAT2_HUMAN (1-355): 1.04e-166: 470: 69.86		ADRB2_HUMAN (1-347): 1.24e-78: 248: 17.55
+	Hs
		815857 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		MTR1A_HUMAN (36-354): 2.47e-66: 215: 62.38
+	Hs
		444686 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		MTR1A_HUMAN (36-354): 2.47e-66: 215: 62.38
+	Hs
		686617 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CCR1_HUMAN (29-357): 1.17e-70: 226: 17.65
+	Hs
		825680 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		MTR1B_HUMAN (1-362): 9.76e-84: 260: 100.00
+	Hs
		670433 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		MTR1A_HUMAN (36-354): 2.47e-66: 215: 62.38
+	Hs
		429010 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		ADRB2_HUMAN (1-347): 1.24e-78: 248: 17.55
+	Hs
		686657 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CCR1_HUMAN (29-357): 1.17e-70: 226: 17.65
+	Dm
		558478 GNAO_DROME (1-355): 9.4e-166: 468: 67.89		GUTR1_DROME (26-327): 2.39e-25: 107: 26.97