HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: RGS19 (P49795)
Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
Gene: RGS19

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	8986788, 8524874
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 217
+	Hs
		834879 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS19_HUMAN (1-217): 1.96e-82: 246: 100.00
+	Hs
		283156 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS20_HUMAN (14-213): 1.27e-67: 214: 56.50
+	Hs
		283183 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS20_HUMAN (14-213): 1.27e-67: 214: 56.50
+	Hs
		207505 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS14_HUMAN (66-207): 2.04e-61: 202: 37.24
+	Hs
		158597 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS12_HUMAN (71-207): 2.87e-57: 197: 36.69
+	Hs
		207517 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS14_HUMAN (66-207): 2.04e-61: 202: 37.24
+	Hs
		391357 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS3_HUMAN (61-213): 7.51e-57: 195: 39.24
+	Hs
		391358 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS4_HUMAN (56-216): 2.71e-61: 192: 36.65
+	Hs
		158608 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS12_HUMAN (71-207): 2.87e-57: 197: 36.69
+	Hs
		391473 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS18_HUMAN (54-215): 3.88e-60: 190: 37.65
+	Hs
		926723 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS17_HUMAN (57-217): 5.89e-63: 196: 59.63
+	Hs
		834937 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS4_HUMAN (56-216): 2.71e-61: 192: 36.65
+	Rn
		500350 GNAI1_RAT (1-355): 6.55e-178: 499: 87.89		RGS4_RAT (56-216): 3.59e-60: 189: 36.65
+	Hs
		926720 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS18_HUMAN (54-215): 3.88e-60: 190: 37.65
+	Hs
		158580 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS13_HUMAN (66-214): 1.63e-58: 183: 40.27
+	Hs
		182439 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS5_HUMAN (68-207): 8.04e-56: 177: 37.14
+	Hs
		180650 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS16_HUMAN (60-205): 9.13e-54: 172: 39.73
+	Hs
		182448 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS5_HUMAN (68-207): 8.04e-56: 177: 37.14
+	Hs
		180657 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS16_HUMAN (60-205): 9.13e-54: 172: 39.73
+	Hs
		210414 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS10_HUMAN (87-202): 2.65e-20: 85.9: 41.03