HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: GBG2 (P59768)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Gene: GNG2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28219978
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 71
+	Hs
		391359 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47
+	Hs
		391377 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41
+	Hs
		887099 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00
+	Hs
		391482 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		GBG8_HUMAN (3-71): 8.51e-26: 91.7: 71.01
+	Hs
		837675 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47
+	Hs
		229233 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		GBG7_HUMAN (4-71): 4.42e-25: 89.7: 70.59
+	Hs
		926667 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41
+	Hs
		926724 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GBG8_HUMAN (3-71): 8.51e-26: 91.7: 71.01
+	Hs
		229239 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GBG7_HUMAN (4-71): 4.42e-25: 89.7: 70.59
+	Hs
		444694 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47
+	Hs
		391360 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		GBG10_HUMAN (4-71): 4.34e-22: 82: 52.94
+	Hs
		444709 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41
+	Hs
		391378 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		GBG5_HUMAN (4-71): 4.11e-21: 79.7: 48.53
+	Hs
		837689 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GBG10_HUMAN (4-71): 4.34e-22: 82: 52.94
+	Hs
		229234 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GBG7_HUMAN (4-71): 4.42e-25: 89.7: 70.59
+	Hs
		926668 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GBG5_HUMAN (4-71): 4.11e-21: 79.7: 48.53
+	Hs
		444695 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GBG10_HUMAN (4-71): 4.34e-22: 82: 52.94
+	Hs
		450990 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		GBG10_HUMAN (4-71): 4.34e-22: 82: 52.94
+	Hs
		444710 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GBG5_HUMAN (4-71): 4.11e-21: 79.7: 48.53
+	Hs
		444701 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GBG11_HUMAN (11-70): 5.68e-17: 69.3: 38.33