HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: IQGA2 (Q13576)
Ras GTPase-activating-like protein IQGAP2
Gene: IQGAP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 1575
+	Hs
		391448 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Hs
		926702 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Hs
		444772 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Hs
		451031 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Mm
		99910 GNAO_MOUSE (1-355): 1.69e-171: 482: 68.45		SYGP1_MOUSE (880-1392): 4.73e-74: 274: 15.61
+	Hs
		837642 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Hs
		670480 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Mm
		99893 GNAZ_MOUSE (1-354): 1.53e-160: 455: 65.82		SYGP1_MOUSE (880-1392): 4.73e-74: 274: 15.61
+	Hs
		580446 GNAZ_HUMAN (1-354): 6.56e-160: 453: 66.38		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Hs
		926621 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Mm
		99949 GNAS2_MOUSE (1-355): 1.67e-144: 415: 38.83		SYGP1_MOUSE (880-1392): 4.73e-74: 274: 15.61