HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: PCP2 (Q8IVA1)
Purkinje cell protein 2 homolog
Gene: PCP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.80	0.700

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	G-alpha~GoLoco
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 136
+	Hs
		926693 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		PCP2_HUMAN (1-136): 1.49e-56: 174: 100.00
+	Hs
		444753 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		PCP2_HUMAN (1-136): 1.49e-56: 174: 100.00
+	Mm
		444632 GNAI2_MOUSE (1-355): 1.99e-178: 500: 98.31		PCP2_MOUSE (18-136): 6.94e-51: 159: 84.03
+	Hs
		926692 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GPSM1_HUMAN (17-136): 4.26e-42: 148: 28.08
+	Mm
		520202 GNAO_MOUSE (1-355): 1.69e-171: 482: 68.45		PCP2_MOUSE (18-136): 6.94e-51: 159: 84.03
+	Hs
		444752 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GPSM1_HUMAN (17-136): 4.26e-42: 148: 28.08
+	Ce
		851057 GNAO_CAEEL (1-355): 2.92e-171: 482: 68.17		Q19955_CAEEL (13-95): 1.56e-28: 110: 35.17
+	Hs
		391380 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		GPSM2_HUMAN (12-83): 5.38e-14: 69.1: 29.17
+	Hs
		926669 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		GPSM2_HUMAN (12-83): 5.38e-14: 69.1: 29.17
+	Hs
		444714 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		GPSM2_HUMAN (12-83): 5.38e-14: 69.1: 29.17
+	Mm
		579655 GNAO_MOUSE (1-355): 1.69e-171: 482: 68.45		GPSM2_MOUSE (14-89): 4.6e-13: 66.8: 31.58