HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: ECT2 (Q9H8V3)
Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)
Gene: ECT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31586073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	G-alpha~RhoGEF
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0030496 - midbody
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 914
+	Hs
		926712 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		444790 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		451036 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		67807 GNAT3_HUMAN (1-355): 3.89e-169: 476: 68.45		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		670486 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		926640 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		837608 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		AKP13_HUMAN (274-912): 7.43e-83: 295: 13.83
+	Hs
		837658 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		ARHGC_HUMAN (316-874): 1.5e-78: 281: 16.35
+	Hs
		1053410 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		ARG28_HUMAN (216-807): 7.17e-88: 309: 12.32
+	Hs
		1053447 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		ARHGC_HUMAN (316-874): 1.5e-78: 281: 16.35
+	Hs
		167075 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		ARHGB_HUMAN (453-651): 2.54e-12: 73.2: 23.53
+	Hs
		167085 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		ARHGB_HUMAN (453-651): 2.54e-12: 73.2: 23.53