HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	25963833, 30104407, 27248496, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 904
+	Hs
		470300 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832523 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832548 H2A3_HUMAN (1-130): 3.34e-68: 203: 99.23		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832623 H2A1C_HUMAN (1-130): 3.23e-68: 203: 98.46		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		594831 H2A1D_HUMAN (1-130): 3.77e-68: 202: 99.23		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832648 H2A1H_HUMAN (1-128): 1.81e-67: 201: 98.44		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832655 H2A1A_HUMAN (1-130): 2.93e-67: 201: 92.37		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		708464 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		391569 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		470283 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708681 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708693 H2A3_HUMAN (1-130): 3.34e-68: 203: 99.23		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708718 H2A1C_HUMAN (1-130): 3.23e-68: 203: 98.46		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		391570 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		594826 H2A1D_HUMAN (1-130): 3.77e-68: 202: 99.23		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708733 H2A1H_HUMAN (1-128): 1.81e-67: 201: 98.44		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708736 H2A1A_HUMAN (1-130): 2.93e-67: 201: 92.37		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708748 H2A1J_HUMAN (1-128): 1.18e-67: 201: 97.66		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		391697 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		391571 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		MCM7_HUMAN (188-886): 0: 707: 27.35