HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.969

Property	Details
Experiments	8945521, 14752096, 11983172, 23934153, 14585496, 15951563, 35907431, 11884585, 11830591
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HAT_KAT11~Histone
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 2414
+	Hs
		998866 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		998781 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		555430 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Mm
		70932 H2A3_MOUSE (1-130): 3.34e-68: 203: 99.23		EP300_MOUSE (1-2414): 0: 1090: 93.01
+	Hs
		391923 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31
+	Hs
		1067005 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		391554 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		631492 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		1067038 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		1066979 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48
+	Hs
		555299 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Hs
		555434 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86
+	Hs
		391802 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13
+	Hs
		391768 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92
+	Hs
		554260 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23
+	Mm
		101453 H2A3_MOUSE (1-130): 3.34e-68: 203: 99.23		F8VPR5_MOUSE (1752-2401): 7.8e-10: 67.1: 12.31
+	Hs
		391823 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		1087066 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		555463 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		1087035 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92