HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: CHD8 (Q9HCK8)
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Gene: CHD8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27248496
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 2581
+	Hs
		555654 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		CHD8_HUMAN (1-2581): 0: 2318: 100.00
+	Hs
		391675 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		1018640 H2A1H_HUMAN (1-128): 1.81e-67: 201: 98.44		CHD3_HUMAN (385-2065): 0: 1037: 23.37
+	Hs
		470387 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		391704 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		1059795 H2A1H_HUMAN (1-128): 1.81e-67: 201: 98.44		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		1059717 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Dm
		332757 H2A_DROME (17-125): 3.74e-60: 182: 88.99		CHDM_DROME (439-2066): 0: 997: 22.94
+	Hs
		1059647 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		555466 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		CHD4_HUMAN (500-2065): 0: 981: 23.88
+	Hs
		229279 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		229433 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		229296 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA5_HUMAN (687-1722): 0: 886: 26.82
+	Hs
		470278 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		SMCA1_HUMAN (654-1705): 0: 875: 26.13
+	Hs
		555306 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA1_HUMAN (654-1705): 0: 875: 26.13
+	Sc
		392360 H2A2_YEAST (16-128): 1.02e-59: 181: 79.65		CHD1_YEAST (589-1846): 0: 853: 26.22
+	Hs
		151474 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD2_HUMAN (373-1741): 0: 803: 25.76
+	Hs
		555359 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA4_HUMAN (69-1478): 0: 806: 23.14
+	Hs
		555358 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA2_HUMAN (101-1489): 0: 797: 22.14
+	Hs
		391728 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD9_HUMAN (2104-2481): 1.87e-106: 385: 29.62