HitPredict

Interactor 1: FINC (P04937)
Fibronectin (FN) [Cleaved into: Anastellin]
Gene: Fn1

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	fn3~fn3, Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3
Common GO terms	GO:0008284 - positive regulation of cell population proliferation GO:0014823 - response to activity GO:0030335 - positive regulation of cell migration GO:0051384 - response to glucocorticoid GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2477 Rn			1 1383
+	Hs
		337733 FINC_HUMAN (1-2477): 0: 1666: 91.69		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		411297 PTPRB_HUMAN (608-865): 8.8e-10: 66.7: 13.28		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Dm
		448231 LAR_DROME (381-1367): 3.11e-72: 272: 13.69		INSR_DROME (28-1383): 0: 991: 34.77
+	Hs
		616944 PTPRD_HUMAN (1721-2328): 3.9e-48: 193: 15.21		EPHA8_HUMAN (663-1323): 1.14e-174: 548: 22.59
+	Hs
		384155 PTPRF_HUMAN (442-1449): 3.55e-105: 378: 14.72		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		337831 PTPRF_HUMAN (442-1449): 3.55e-105: 378: 14.72		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		337952 TENA_HUMAN (1265-2363): 3.06e-96: 350: 17.98		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		234508 DSCAM_HUMAN (424-1189): 3.27e-47: 189: 13.24		MERTK_HUMAN (810-1302): 3.9e-61: 230: 31.54
+	Hs
		616937 PTPRB_HUMAN (608-865): 8.8e-10: 66.7: 13.28		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		384777 PTPRS_HUMAN (516-909): 8.01e-16: 86.7: 12.26		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		337941 PTPRD_HUMAN (1721-2328): 3.9e-48: 193: 15.21		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		1031989 PTPRS_HUMAN (516-909): 8.01e-16: 86.7: 12.26		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		385252 TITIN_HUMAN (836-1083): 2.28e-10: 69: 6.92		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		384278 PTPRB_HUMAN (608-865): 8.8e-10: 66.7: 13.28		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		338769 TITIN_HUMAN (836-1083): 2.28e-10: 69: 6.92		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		337940 PTPRB_HUMAN (608-865): 8.8e-10: 66.7: 13.28		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		338521 Q59G22_HUMAN (172-387): 1.9e-09: 65.5: 24.77		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383611 PTPRB_HUMAN (608-865): 8.8e-10: 66.7: 13.28		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83