Interactor 1: IGF1 (P05019)
Insulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C)
Gene: IGF1
Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.618 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 8452530 |
| Identification Methods | competition binding |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Insulin~fn3, Furin-like~Insulin, Insulin~Recep_L_domain |
| Common GO terms | GO:0005159 - insulin-like growth factor receptor binding GO:0008284 - positive regulation of cell population proliferation GO:0030335 - positive regulation of cell migration GO:0032148 - activation of protein kinase B activity GO:0043410 - positive regulation of MAPK cascade and 6 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
