HitPredict

Interactor 1: IGF1 (P05019)
Insulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C)
Gene: IGF1

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 1852007, 21645859, 8452530
Identification Methods pull down, surface plasmon resonance, mass spectrometry study of hydrogen/deuterium exchange, competition binding, affinity technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Insulin~fn3, Furin-like~Insulin, Insulin~Recep_L_domain
Common GO terms GO:0005158 - insulin receptor binding
GO:0007165 - signal transduction
GO:0008284 - positive regulation of cell population proliferation
GO:0030335 - positive regulation of cell migration
GO:0035867 - alphav-beta3 integrin-IGF-1-IGF1R complex
and 6 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 195
Hs

1 1367
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024