HitPredict

Interactor 1: IGF1 (P05019)
Insulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C)
Gene: IGF1

Interactor 2: IBP4 (P22692)
Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)
Gene: IGFBP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.909

The method score is based on:

Property Details
Experiments 7683646, 9722589, 16924115, 15642270
Identification Methods pull down, isothermal titration calorimetry, x-ray crystallography, molecular sieving
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains IGFBP~Insulin, Insulin~Thyroglobulin_1
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0007165 - signal transduction
GO:0043410 - positive regulation of MAPK cascade
GO:0043568 - positive regulation of insulin-like growth factor receptor signaling pathway
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 195
Hs

1 258
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024