HitPredict

Interactor 1: SCG1 (P05060)
Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide]
Gene: CHGB

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.671

Property	Details
Experiments	24510904, 29513927, 24947832
Identification Methods	pull down, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 677 Hs			1 2527
+	Hs
		1130644 MDN1_HUMAN (23-457): 9.59e-57: 211: 12.37		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130349 THOC2_HUMAN (51-396): 1.85e-33: 140: 14.08		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		393790 SCG1_HUMAN (1-677): 8.53e-119: 371: 100.00		LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38
+	Hs
		393801 SCG1_HUMAN (1-677): 8.53e-119: 371: 100.00		MFHA1_HUMAN (838-1119): 1.5e-30: 134: 16.95
+	Dm
		1363782 FUTSC_DROME (38-657): 8.8e-10: 64.4: 13.82		Q9VDJ9_DROME (1810-2154): 3.35e-55: 216: 26.46