HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: JUN (P05412)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene: JUN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	20195357, 32814053
Identification Methods	pull down, two hybrid array, two hybrid pooling approach, validated two hybrid, display technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003677 - DNA binding GO:0019899 - enzyme binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 331
+	Mm
		404112 A4_MOUSE (1-770): 0: 1016: 96.62		JUN_MOUSE (1-331): 5.76e-86: 263: 94.61
+	Hs
		394074 A4_HUMAN (19-770): 0: 999: 100.00		JUND_HUMAN (5-331): 5.93e-47: 163: 45.86
+	Hs
		394053 A4_HUMAN (19-770): 0: 999: 100.00		ATF2_HUMAN (47-331): 1.64e-38: 144: 17.33
+	Hs
		401885 APLP2_HUMAN (3-769): 0: 858: 49.17		JUN_HUMAN (1-331): 8.11e-87: 266: 100.00
+	Hs
		394062 A4_HUMAN (19-770): 0: 999: 100.00		CREB1_HUMAN (54-307): 2.89e-29: 116: 14.84
+	Hs
		566752 APLP2_HUMAN (3-769): 0: 858: 49.17		JUNB_HUMAN (1-331): 3.94e-63: 205: 43.89