HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: LAMC1 (P11047)
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
Gene: LAMC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	21244100, 21832049
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0007155 - cell adhesion GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 1609
+	Hs
		395555 A4_HUMAN (19-770): 0: 999: 100.00		NOTC4_HUMAN (523-1105): 3.62e-48: 191: 12.92
+	Hs
		394302 A4_HUMAN (19-770): 0: 999: 100.00		NOTC1_HUMAN (269-659): 2.81e-33: 143: 12.34
+	Hs
		317782 A4_HUMAN (19-770): 0: 999: 100.00		NET1_HUMAN (334-487): 7.39e-13: 75.3: 24.72
+	Hs
		970671 CO7A1_HUMAN (234-355): 3.84e-23: 108: 32.80		LAMB3_HUMAN (386-723): 2.62e-23: 110: 16.35
+	Hs
		172657 CO7A1_HUMAN (234-355): 3.84e-23: 108: 32.80		LAMA5_HUMAN (933-1113): 9.18e-11: 69.5: 18.79
+	Hs
		970672 CO7A1_HUMAN (234-355): 3.84e-23: 108: 32.80		LAMC2_HUMAN (249-407): 1.06e-09: 65.6: 22.56