HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: KS6B1 (P23443)
Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)
Gene: RPS6KB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	21832049, 32814053
Identification Methods	pull down, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0009986 - cell surface GO:0045931 - positive regulation of mitotic cell cycle GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 525
+	Hs
		394195 A4_HUMAN (19-770): 0: 999: 100.00		AKT2_HUMAN (3-416): 5.02e-151: 442: 38.66
+	Hs
		394194 A4_HUMAN (19-770): 0: 999: 100.00		AKT1_HUMAN (34-418): 1.81e-150: 440: 39.90
+	Hs
		616703 APLP2_HUMAN (3-769): 0: 858: 49.17		KS6B1_HUMAN (8-525): 0: 573: 100.00
+	Hs
		394562 A4_HUMAN (19-770): 0: 999: 100.00		KPCE_HUMAN (13-420): 6.39e-143: 430: 33.89
+	Hs
		394075 A4_HUMAN (19-770): 0: 999: 100.00		KAPCA_HUMAN (80-397): 6.73e-143: 417: 36.79
+	Hs
		394747 A4_HUMAN (19-770): 0: 999: 100.00		KS6A2_HUMAN (4-412): 5.84e-105: 332: 23.99
+	Hs
		270362 A4_HUMAN (19-770): 0: 999: 100.00		KS6A5_HUMAN (4-349): 1.07e-103: 330: 24.73
+	Hs
		396020 A4_HUMAN (19-770): 0: 999: 100.00		KS6A6_HUMAN (3-412): 3.24e-101: 322: 22.75
+	Hs
		395426 A4_HUMAN (19-770): 0: 999: 100.00		SGK3_HUMAN (70-417): 5.67e-95: 299: 45.13
+	Hs
		395809 A4_HUMAN (19-770): 0: 999: 100.00		SGK2_HUMAN (78-413): 1.3e-94: 293: 45.35
+	Hs
		566370 APLP2_HUMAN (3-769): 0: 858: 49.17		KPCA_HUMAN (4-419): 2.83e-142: 426: 35.55