HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: PDIA3 (P30101)
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)
Gene: PDIA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	21832049, 15896298, 32814053
Identification Methods	pull down, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen GO:0009986 - cell surface GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 505
+	Mm
		517697 A4_MOUSE (1-770): 0: 1016: 96.62		ERP44_MOUSE (370-500): 1.33e-25: 110: 22.79
+	Mm
		517690 A4_MOUSE (1-770): 0: 1016: 96.62		PDIA6_MOUSE (372-478): 3.61e-25: 109: 31.48
+	Hs
		395491 A4_HUMAN (19-770): 0: 999: 100.00		TMX3_HUMAN (375-482): 4.46e-27: 115: 37.27
+	Hs
		395608 A4_HUMAN (19-770): 0: 999: 100.00		ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64
+	Hs
		394737 A4_HUMAN (19-770): 0: 999: 100.00		PDIA6_HUMAN (385-471): 3.13e-10: 64.3: 40.91
+	Hs
		987541 APLP2_HUMAN (3-769): 0: 858: 49.17		ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64
+	Hs
		518048 CO6A3_HUMAN (251-348): 1.13e-23: 110: 28.57		PDIA3_HUMAN (1-505): 6.41e-165: 478: 100.00