HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: COIA1 (P39060)
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]
Gene: COL18A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	28514442, 19542224, 28106549
Identification Methods	affinity chromatography technology, pull down, surface plasmon resonance array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0007155 - cell adhesion GO:0008285 - negative regulation of cell population proliferation and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 1754
+	Hs
		395255 A4_HUMAN (19-770): 0: 999: 100.00		COMA1_HUMAN (1205-1671): 2.24e-31: 137: 20.38
+	Hs
		394701 A4_HUMAN (19-770): 0: 999: 100.00		CO4A6_HUMAN (1192-1673): 6.92e-26: 118: 18.92
+	Hs
		394021 A4_HUMAN (19-770): 0: 999: 100.00		COBA1_HUMAN (598-1065): 1.67e-25: 117: 28.66
+	Hs
		358660 CO7A1_HUMAN (234-355): 3.84e-23: 108: 32.80		CO4A1_HUMAN (783-1673): 7.78e-70: 262: 22.25
+	Mm
		1144386 CO7A1_MOUSE (234-343): 3.63e-26: 118: 33.93		CO7A1_MOUSE (1240-1670): 7.73e-28: 125: 16.89
+	Dm
		435980 Q7KN04_DROME (10-356): 3.01e-34: 142: 13.06		CO4A1_DROME (592-732): 1.21e-10: 68.9: 14.18
+	Hs
		358498 CO7A1_HUMAN (234-355): 3.84e-23: 108: 32.80		CO1A1_HUMAN (614-901): 6.51e-11: 70.1: 24.83
+	Mm
		93247 E9PWQ3_MOUSE (250-345): 1.6e-21: 103: 27.08		E9PWQ3_MOUSE (1558-1684): 6.7e-12: 73.1: 10.53