Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP
Interactor 2: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 1.00 | 0.969 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28351972, 23209290, 21163940, 21115843, 9223340, 32814053, 11083918 |
| Identification Methods | fluorescent resonance energy transfer, affinity chromatography technology, two hybrid, protease assay, anti bait coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid |
| Interaction Type | direct interaction, physical association, association, protein cleavage |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Beta-APP~Presenilin |
| Common GO terms | GO:0001934 - positive regulation of protein phosphorylation GO:0002265 - astrocyte activation involved in immune response GO:0005743 - mitochondrial inner membrane GO:0005783 - endoplasmic reticulum GO:0005790 - smooth endoplasmic reticulum and 27 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Last updated: 15 Jul 2024
