HitPredict

Interactor 1: ACTN1 (P05094)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: ZYX (Q04584)
Zyxin
Gene: ZYX

Species: Gallus gallus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.534

Property	Details
Experiments	1541635
Identification Methods	far western blotting, molecular sieving, solid phase assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001725 - stress fiber GO:0005925 - focal adhesion GO:0051393 - alpha-actinin binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 893 Gg			1 542
+	Hs
		521553 ACTN1_HUMAN (4-893): 0: 640: 97.75		ZYX_HUMAN (8-540): 5.96e-64: 220: 44.39
+	Hs
		521634 ACTN1_HUMAN (4-893): 0: 640: 97.75		TES_HUMAN (221-530): 1.34e-59: 204: 18.55
+	Hs
		211588 ACTN4_HUMAN (12-893): 0: 592: 86.74		ZYX_HUMAN (8-540): 5.96e-64: 220: 44.39
+	Hs
		725659 ACTN2_HUMAN (3-893): 0: 583: 79.69		ZYX_HUMAN (8-540): 5.96e-64: 220: 44.39
+	Hs
		211685 ACTN4_HUMAN (12-893): 0: 592: 86.74		TES_HUMAN (221-530): 1.34e-59: 204: 18.55
+	Hs
		521623 ACTN1_HUMAN (4-893): 0: 640: 97.75		PDLI7_HUMAN (81-463): 1.59e-31: 128: 17.83
+	Hs
		211672 ACTN4_HUMAN (12-893): 0: 592: 86.74		PDLI7_HUMAN (81-463): 1.59e-31: 128: 17.83
+	Hs
		725704 ACTN2_HUMAN (3-893): 0: 583: 79.69		PDLI7_HUMAN (81-463): 1.59e-31: 128: 17.83
+	Mm
		1186636 ACTN1_MOUSE (4-893): 0: 639: 97.42		PDLI5_MOUSE (130-407): 2.61e-12: 71.2: 11.74
+	Hs
		963447 SPTB2_HUMAN (167-755): 1.34e-10: 67.8: 11.51		TES_HUMAN (221-530): 1.34e-59: 204: 18.55
+	Hs
		963432 SPTB2_HUMAN (167-755): 1.34e-10: 67.8: 11.51		PDLI7_HUMAN (81-463): 1.59e-31: 128: 17.83
+	Hs
		506846 SPTB1_HUMAN (222-815): 8.66e-09: 61.6: 10.98		PDLI7_HUMAN (81-463): 1.59e-31: 128: 17.83