HitPredict

Interactor 1: INHA (P05111)
Inhibin alpha chain
Gene: INHA

Interactor 2: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10746731
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0034673 - inhibin-betaglycan-ActRII complex GO:0034711 - inhibin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 366 Hs			1 513
+	Hs
		451817 INHBB_HUMAN (14-365): 3.87e-92: 283: 20.22		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		520099 BMP4_HUMAN (54-365): 1.26e-89: 277: 18.68		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		520070 BMP2_HUMAN (54-365): 4.52e-85: 264: 14.41		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		155757 GDF8_HUMAN (16-365): 6.1e-96: 292: 16.16		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		451820 INHBB_HUMAN (14-365): 3.87e-92: 283: 20.22		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Mm
		739910 INHA_MOUSE (18-366): 3.17e-117: 346: 80.23		ACVR1_MOUSE (47-493): 2.64e-116: 354: 30.27
+	Hs
		312855 GDF11_HUMAN (13-365): 5.97e-90: 277: 18.70		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Mm
		646093 GDF11_MOUSE (13-365): 1.49e-89: 276: 18.70		AVR2B_MOUSE (4-513): 1.8e-137: 409: 64.42
+	Hs
		520077 BMP2_HUMAN (54-365): 4.52e-85: 264: 14.41		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		122281 BMP4_HUMAN (54-365): 1.26e-89: 277: 18.68		BMR1B_HUMAN (59-488): 2.3e-130: 390: 33.55
+	Hs
		520110 BMP4_HUMAN (54-365): 1.26e-89: 277: 18.68		BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41
+	Hs
		122280 BMP2_HUMAN (54-365): 4.52e-85: 264: 14.41		BMR1B_HUMAN (59-488): 2.3e-130: 390: 33.55
+	Mm
		1225203 GDF11_MOUSE (13-365): 1.49e-89: 276: 18.70		ACV1C_MOUSE (60-482): 6.71e-126: 378: 32.31
+	Hs
		451821 INHBB_HUMAN (14-365): 3.87e-92: 283: 20.22		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		520071 BMP2_HUMAN (54-365): 4.52e-85: 264: 14.41		BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41
+	Hs
		520153 BMP4_HUMAN (54-365): 1.26e-89: 277: 18.68		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Mm
		1145509 GDF11_MOUSE (13-365): 1.49e-89: 276: 18.70		TGFR1_MOUSE (60-488): 2.44e-117: 356: 31.95
+	Hs
		520078 BMP2_HUMAN (54-365): 4.52e-85: 264: 14.41		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		451818 INHBB_HUMAN (14-365): 3.87e-92: 283: 20.22		ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41
+	Mm
		1142443 GDF11_MOUSE (13-365): 1.49e-89: 276: 18.70		ACV1B_MOUSE (2-488): 1.87e-112: 344: 28.22