HitPredict

Interactor 1: KPCG (P05129)
Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)
Gene: PRKCG

Interactor 2: EPHB1 (P54762)
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
Gene: EPHB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20395553
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 697 Hs			1 984
+	Hs
		665151 AKT1_HUMAN (215-677): 1.23e-151: 450: 33.68		EPHA2_HUMAN (17-978): 0: 1032: 46.58
+	Hs
		665243 KS6A2_HUMAN (247-664): 7.56e-90: 297: 22.94		EPHA2_HUMAN (17-978): 0: 1032: 46.58
+	Hs
		1072587 KPCD2_HUMAN (88-189): 1.05e-23: 108: 31.82		EPHA7_HUMAN (1-981): 0: 1151: 56.96
+	Hs
		537714 KPCA_HUMAN (1-683): 0: 725: 70.03		INSRR_HUMAN (278-912): 3.5e-157: 499: 25.72
+	Hs
		784013 KPCI_HUMAN (6-85): 1.85e-12: 72.4: 39.29		EPHA7_HUMAN (1-981): 0: 1151: 56.96
+	Hs
		783958 KPCI_HUMAN (6-85): 1.85e-12: 72.4: 39.29		EPHA5_HUMAN (1-981): 0: 1143: 55.78
+	Hs
		435552 AKT1_HUMAN (215-677): 1.23e-151: 450: 33.68		IGF1R_HUMAN (390-883): 2.15e-141: 458: 30.71
+	Hs
		537733 KPCD_HUMAN (3-166): 8.84e-63: 223: 38.60		INSRR_HUMAN (278-912): 3.5e-157: 499: 25.72
+	Hs
		411362 KPCD_HUMAN (3-166): 8.84e-63: 223: 38.60		INSR_HUMAN (275-940): 4.21e-150: 482: 25.81
+	Hs
		412046 AKT1_HUMAN (215-677): 1.23e-151: 450: 33.68		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		412392 KS6B2_HUMAN (290-695): 2.01e-149: 444: 36.43		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		412203 KS6A2_HUMAN (247-664): 7.56e-90: 297: 22.94		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Mm
		546263 AKT1_MOUSE (215-677): 5.19e-152: 451: 33.89		INSR_MOUSE (338-495): 1.19e-09: 64.6: 16.76
+	Hs
		412145 KPCD_HUMAN (3-166): 8.84e-63: 223: 38.60		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Mm
		411915 KPCE_MOUSE (3-245): 3.78e-57: 208: 35.16		LCK_MOUSE (577-879): 1.39e-64: 228: 41.12
+	Hs
		412141 KPCT_HUMAN (21-244): 1.6e-56: 206: 31.76		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		412067 KPCI_HUMAN (6-85): 1.85e-12: 72.4: 39.29		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54