HitPredict

Interactor 1: IPSP (P05154)
Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)
Gene: SERPINA5

Interactor 2: HGFA (Q04756)
Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]
Gene: HGFAC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 655
+	Hs
		371463 IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00		KLKB1_HUMAN (360-647): 3.66e-95: 308: 34.34
+	Hs
		341126 IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00		THRB_HUMAN (115-645): 9.28e-87: 285: 24.11
+	Mm
		581130 SPA3C_MOUSE (6-406): 9.21e-169: 480: 42.86		THRB_MOUSE (115-645): 1.32e-88: 290: 23.08
+	Hs
		341480 IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00		UROK_HUMAN (242-649): 1.3e-73: 245: 34.15
+	Hs
		341527 IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00		TPA_HUMAN (141-647): 4.75e-68: 234: 29.56
+	Hs
		397632 IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00		ACRO_HUMAN (386-649): 8.97e-64: 218: 28.83
+	Hs
		341138 SPB6_HUMAN (40-406): 4.31e-140: 406: 32.28		THRB_HUMAN (115-645): 9.28e-87: 285: 24.11
+	Mm
		936828 IPSP_MOUSE (1-406): 1.78e-157: 451: 62.16		TM11E_MOUSE (387-646): 8.09e-67: 227: 31.68
+	Hs
		344349 AACT_HUMAN (7-406): 1.07e-161: 462: 46.31		KLK13_HUMAN (399-647): 1.06e-63: 213: 32.02
+	Hs
		341478 PAI2_HUMAN (41-406): 4.96e-146: 422: 28.09		UROK_HUMAN (242-649): 1.3e-73: 245: 34.15
+	Hs
		341311 SPB8_HUMAN (41-406): 4.69e-141: 408: 32.63		FA10_HUMAN (236-654): 5.74e-78: 258: 24.42
+	Mm
		430527 A1AT1_MOUSE (25-406): 2.77e-154: 443: 40.67		Q9Z1R9_MOUSE (412-648): 2.25e-66: 219: 34.60
+	Hs
		341525 PAI2_HUMAN (41-406): 4.96e-146: 422: 28.09		TPA_HUMAN (141-647): 4.75e-68: 234: 29.56
+	Hs
		719380 SPB6_HUMAN (40-406): 4.31e-140: 406: 32.28		TM11A_HUMAN (418-646): 1.54e-74: 247: 33.04
+	Hs
		1218311 SPA12_HUMAN (6-406): 1.72e-146: 423: 36.52		TM11E_HUMAN (390-646): 1.78e-66: 225: 31.01
+	Hs
		371455 IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00		FA11_HUMAN (394-646): 8.66e-39: 153: 34.75
+	Hs
		341545 SPB6_HUMAN (40-406): 4.31e-140: 406: 32.28		TPA_HUMAN (141-647): 4.75e-68: 234: 29.56
+	Hs
		428671 SPB8_HUMAN (41-406): 4.69e-141: 408: 32.63		TRY1_HUMAN (412-649): 2.39e-70: 230: 33.61
+	Hs
		375826 IPSP_HUMAN (1-406): 3.48e-172: 488: 100.00		PROC_HUMAN (361-654): 1.07e-37: 147: 33.13
+	Hs
		177775 A1AT_HUMAN (6-406): 9.76e-161: 460: 43.07		TMPS2_HUMAN (405-646): 5.22e-37: 146: 35.63